Abstract
BACKGROUND: Prior works have studied the impact of social determinants on various cancers but there is limited analysis on eye-orbit cancers. Current literature tends to focus on socioeconomic status and race, with sparse analysis of interdisciplinary contributions. We examined social determinants as measured by the Centers for Disease Control and Prevention (CDC) Social Vulnerability Index (SVI), quantifying eye and orbit melanoma disparities across the United States. METHODS: A retrospective review of 15,157 patients diagnosed with eye-orbit cancers in the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2017 was performed, extracting 6139 ocular melanomas. SVI scores were abstracted and matched to SEER patient data, with scores generated by weighted averages per population density of county's census tracts. Primary outcome was months survived, while secondary outcomes were advanced staging, high grading, and primary surgery receipt. RESULTS: With increased total SVI score, indicating more vulnerability, we observed significant decreases of 23.1% in months survival for melanoma histology (p < 0.001) and 19.6-39.7% by primary site. increasing total svi showed increased odds of higher grading (odds ratio [or] 1.20, 95% confidence interval [ci] 1.02-1.43) and decreased odds of surgical intervention (or 0.94, 95% ci 0.92-0.96). of the four themes, higher magnitude contributions were observed with socioeconomic status (26.0%) and housing transportation (14.4%), while lesser magnitude contributions were observed with minority language status (13.5%) and household composition (9.0%). conclusions: increasing social vulnerability, as measured by the cdc svi and its subscores, displayed significant detrimental trends in prognostic and treatment factors for adult eye-orbit melanoma. subscores quantified which social determinants contributed most to disparities. this lays groundwork for providers to target the highest-impact social determinant for non-clinical factors in patient care.> 0.001)>