Abstract
Obstructive sleep apnea (OSA) negatively impacts health-related quality of life (HR-QoL) in adults, but few pediatric studies have explored this relationship or the relationships between HR-QoL domains. Patients age 8-17 years visiting the sleep laboratory from 07/2019 to 01/2020 for overnight polysomnography (PSG) participated in the study. Controls seen for problems other than sleep disturbance were recruited from the Department of Pediatrics outpatient clinics. HR-QoL was assessed by PROMIS profile questionnaires, Version 2.0. Statistical analysis was conducted using R 3.6.0. One hundred and twenty-two patients were included in the final analysis. Sixty-four patients were males (52.4%). Twenty-nine (23.8%) had mild OSA, 8 (6.6%) moderate OSA, 17 (13.9%) severe OSA, 46 (37.7%) were without OSA and 22 (18.0%) were controls. Patients referred for polysomnography had lower physical function mobility compared to controls (p=0.03). Increased OSA severity was linearly associated with a decrease in physical function mobility (p=0.008). Correlation analysis revealed that physical function mobility was positively associated with Total Sleep Time (TST, p=0.02) and negatively associated with apnea-hypopnea index (AHI, p=0.01). Age was positively associated with fatigue (p=0.02) and negatively associated with deep sleep (p<0.001). regression analysis revealed that physical function mobility was positively associated with tst (p="0.02)" and negatively associated with ahi (p="0.04)" after controlling for age, sex and number of arousals. osa and total sleep time were associated with problems with physical function mobility after adjusting for age, sex and number of arousals.>
