Hashizume Laboratory

The research interest of our laboratory lies in identifying new effective therapies to improve the outcome of children with brain tumors. Our laboratory studies to understand the biology and molecular mechanisms that promote cancer development and progression, and would accordingly reveal potential therapeutic targets. We utilize animal model systems that faithfully recapitulate the biology and genetics of human brain tumors. Animal model systems enhance the testing of new therapeutic agents being considered for clinical trials, as well as new therapeutic approaches that bypass the blood-brain barrier, such as convection enhanced delivery and intranasal delivery.

Research Topics

Pediatric Brain Tumor
Epigenetic Therapy
PDX Models
DIPG Model
AT/RT Model
Intranasal Delivery


Rintaro Hashizume, MD, PhD

Principal Investigator