Perinatal Origins of Disease
Investigating the mechanisms and biological and environmental factors during pregnancy and early infancy that changes health and disease trajectories throughout the lifespan.
The Perez Laboratory focuses on hyperoxic lung injury, neonatal lung and pulmonary vascular development, and the effects of exogenous glucocorticoids on the developing lung. We utilize a neonatal mouse model of hyperoxic lung injury that mimics the lung disease of infants with bronchopulmonary dysplasia, a chronic lung disease of formerly premature infants. Our work focuses on the impact of glucocorticoids, medications commonly used in neonatal intensive care unit, on pulmonary development, including effects of steroids on pulmonary vascular signaling.