Abstract
This phase I trial studies the side effects and the best dose of adavosertib when given
together with local radiation therapy in treating children with newly diagnosed diffuse
intrinsic pontine gliomas. Adavosertib may stop the growth of tumor cells by blocking some of
the enzymes needed for cell growth. Radiation therapy uses high energy x-rays, gamma rays,
neutrons, protons, or other sources to kill tumor cells and shrink tumors. Giving adavosertib
with local radiation therapy may work better than local radiation therapy alone in treating
diffuse intrinsic pontine gliomas.
