Abstract
Project Summary We propose an ancillary study to The Heart and Lung Failure Pediatric Insulin
Titration trial (HALF PINT), which is investigating the impact of normalizing blood glucose
using insulin infusions on clinical outcomes among children with hyperglycemia and heart and
lung failure. In this ancillary study, we will measure plasma levels of inflammatory,
coagulation, and fibrinolysis proteins and genotype DNA for polymorphisms among patients
enrolled in the HALF PINT trial. The results from this ancillary study will help us to
understand potential mechanisms through which normalizing blood glucose provides benefit,
which may lead to development of new therapeutic strategies in critically ill children
