Abstract
The overarching goal of this proposal is to identify modifiable behavioral strategies based
on patient-reported outcomes (PROs) and health-related quality of life (HRQOL) that will
improve hydroxyurea (HU) adherence among adolescents and young adults with sickle cell
disease (SCD). In this proposed study, we intend to test the functionality of a PROs-toolbox
feature, which will be integrated into our existing smartphone application platform
(SCD-app), over a 24-week period in a cohort of SCD patients and their caregivers.
