Abstract
This study consists of four parts, Parts A, B, C, and D.
- Part A is a single dose pharmacokinetic (PK) study in pediatric participants with Sickle
Cell Disease ages 6 to 17 years.
- Part B is a multiple dose, safety, exploratory, efficacy, and PK study in adolescent
participants with Sickle Cell Disease ages 12 to 17 years.
- Part C is a multiple dose, safety, tolerability, and PK study, which includes the
assessment of hematological effects and the effect on TCD flow velocity of voxelotor in
pediatric participants with Sickle Cell Disease ages 4 to 17 years.
- Part D is a multiple dose, safety, tolerability, and PK study, which examines the
hematological effects of voxelotor in pediatric participants with Sickle Cell Disease
ages 6 months to < 4 years.

