Basic Science
Developmental Biology

Engineered Solutions for Health

Fertility and Hormone Preservation and Restoration

Host-Microbial Interactions, Inflammation, and Immunity

Human Molecular Genetics and Physiology

Immune Deviation and Disease

Injury, Repair, and Regeneration

Molecular and Translational Cancer Biology

Neurobiology

Perinatal Origins of Disease
Basic and Preclinical Science
We investigate essential functions of biological processes and fundamental mechanisms of diseases and disorders affecting children’s health. Our lab-based programs are organized into virtual scientific neighborhoods that promote collaborations.
Learn more
Clinical Trials
Find Clinical Studies

Last Viewed:

Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery
Clinical and Community Trials
Our work translates the discoveries of basic science into promising clinical applications. Multidisciplinary teams of researchers collaborate on clinical research on a range of specialties and conditions organized into program areas.
Learn more
Population Science
Smith Child Health Outcomes, Research and Evaluation Center

Macy Laboratory

ARISE Health Laboratory

Center for Allergy and Asthma Research

Foster Health Laboratory

Genetics and Justice Laboratory

I+HEAL Laboratory

Pediatric Practice Research Group

TRICAM
Community, Population Health, and Outcomes
We drive the research on biological, psychological, social, behavioral, and environmental causes and influencers of common and prominent child health problems to generate evidence for clinical and public health interventions.
Learn more
Quant Science
Researchers

Find Researchers

Our Researchers
Our diverse team of researchers are influential leaders in investigating pediatric health issues and diseases, and include physicians, scientists, postdocs, coordinators, statisticians, data analysts, trainees, and others who routinely collaborate with medical centers, academic institutions, and community partners across the globe.
See our researchers

Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery

Abstract

This is a multi center, Phase I, Phase II and surgical study of the CX-4945 drug (silmitasertib sodium) for patients with recurrent SHH (Sonic Hedgehog) medulloblastoma

View full study on ClinicalTrials.gov

ClinicalTrials.gov ID:

NCT03904862

Principal Investigator:

Alicia C Lenzen

Study Status:

Currently Recruiting

Stanley Manne Children's Research Institute
Louis A. Simpson and Kimberly K. Querrey Biomedical Research Center

303 East Superior Street
Chicago, IL 60611

312.503.1499