Abstract
The primary objective of this study is to better understand factors contributing to
variations in hydroxyurea (HU) adherence behavior in adolescents and young adults (AYA) with
sickle cell disease (SCD). To meet this objective, the researchers will conduct a prospective
cohort study to determine the longitudinal relationship between HU adherence and
health-related quality of life (HRQOL) overtime among AYA with SCD. The long-term goal of
this research is to promote medication adherence behavior and improve health outcomes in AYA
with SCD.
