Abstract
TReatment for ImmUne Mediated PathopHysiology (TRIUMPH) is a multi-center, three arm, randomized, controlled trial of immunosuppressive therapy for children with acute liver failure. The study will determine if suppressing inflammatory responses with either corticosteroids or equine anti-thymocyte globulin therapy improves survival for children with this rare, life-threatening condition.
The Pediatric Acute Liver Failure Immune Response Network (PALF IRN) is a national network comprised of 20 regional referral centers for pediatric acute liver failure. The network is directed by Dr. Estella M. Alonso, a pediatric hepatologist with long standing expertise in the management of acute liver failure in children and Dr. Valerie L. Durkalski, a clinical trials specialist with extensive experience in running multicenter trials.
