Abstract
TITRE - Trial of Indication-based Transfusion of Red Blood Cells in ECMO, is a multicenter,
prospective, randomized clinical trial. The overarching goal of TITRE is to determine whether
restricting red blood cell (RBC) transfusion according to an indication-based strategy for
those with bleeding and/or deficit of tissue oxygen delivery, compared with transfusion based
on center-specific hemoglobin or hematocrit thresholds, can reduce organ dysfunction and
improve later neurodevelopment in critically ill children receiving Extracorporeal Membrane
Oxygenation (ECMO) support.
