Abstract
OBJECTIVE: To estimate the association between lung hyperinflation and the time to successful transition to home ventilators in infants with sBPD and chronic respiratory failure. DESIGN/METHODS: Infants with sBPD <32 weeks gestation who received tracheostomies were identified. hyperinflation was the main exposure. time from tracheostomy to successful transition to the home ventilator was the main outcome. kaplan-meier and multivariable cox proportional hazards were used to estimate the relationships between hyperinflation and the main outcome. results: sixty-two infants were included 26 42 were hyperinflated. eleven died before transition and 51 successfully transitioned. hyperinflation was associated with both mortality 31 vs 8.3 p=" 0.02)" and an increased duration 72 vs. 56 days to successful transition hazard ratio hr=" 0.38," 95 ci: 0.19 0.76 p=" 0.006)." growth velocity was similar after tracheostomy placement. conclusions: in infants with chronic respiratory failure and sbpd><32 weeks gestation hyperinflation is related to mortality and inpatient morbidities.>
