Abstract
OBJECTIVE: To compare long-term outcomes of pediatric liver transplant (LT) recipients off immunosuppression (IS) with matched controls on IS using data from the Society of Pediatric Liver Transplant (SPLIT) registry. STUDY DESIGN: This was a retrospective case-control study. SPLIT participants <18 years of age 4years after isolated lt and off is for 1year cases were age- and sex-matched 1:2 to patients with the same primary diagnosis and post-lt follow-up duration controls. primary outcomes included retransplantation allograft rejection is comorbidities and prevalence of split-derived composite ideal outcome c-io achieved at the end of the follow-up period. differences were compared using multiple linear regression for continuous outcomes and logistic regression for dichotomous data. results: the study cohort was composed of 33 cases 42.4 male 60.6 biliary atresia median age at lt of 0.7 p25 p75 0.5 1.6 years median is withdrawal time of 9 p25 p75 6 12 years after lt and 66 age- and sex-matched controls. no cases required retransplantation. cases and controls had similar growth parameters laboratory values calculated glomerular filtration rates rates of post-transplant lymphoproliferative disease graft rejection and attainment of c-io. conclusions: no differences in allograft rejection rates is complications or c-io prevalence were seen between split patients off is and age- and sex-matched controls remaining on is. discontinuation of is most commonly occurred in the context of rigorously designed is withdrawal trials. the available sample size was small affecting generalizability to the broader pediatric lt population.>
