Bioinformatics Support Services

Bioinformatics is the application of science and technology for collecting, searching, analyzing, and maintaining genome-scale data. Bioinformatics uses big data and molecular biology to answer medical science questions.

The bioinformatics team supports the Ann & Robert H. Lurie Children’s Hospital of Chicago research enterprise through the Stanley Manne Children’s Research Institute Quantitative Science Pillar. Bioinformaticians with expertise spanning a variety of molecular technologies are available to aid in planning, executing, interpreting, and reporting of genome-scale studies. The bioinformatics team—who have collectively authored more than 120 peer-reviewed scientific papers—specializes in the visualization and communication of concepts at the interface of computing and medical science.

The bioinformatics team has developed reproducible bioinformatic analysis pipelines for common analyses with common experimental designs. These highly automated analysis pipelines are offered as packages. Packaged services include:

  • Whole-genome (WGS) and whole-exome sequence (WES) analysis
  • Differential gene expression analysis (bulk RNA-seq)
  • Differential chromatin accessibility analysis (ATAC-seq)

The bioinformatics team is committed to providing bioinformatic support for researchers across Lurie Children’s and are prepared to perform analyses not covered by our packages. Such project-specific analyses include but are not limited to:

  • Chromatin structure analysis (Hi-C, ChIP, CUT&RUN)
  • Copy number analysis and comparative hybridization approaches
  • Genome-wide SNP arrays
  • Single cell RNA-seq analysis
  • CRISPR screening analysis

The bioinformatics team also provides consultation services, which include:

  • Advising on study design
  • Custom pipeline development
  • Custom visualization and development of interactive data communication tools

In addition to their role in supporting research efforts at Manne Research Institute, Lurie’s bioinformaticians facilitate genetic testing through the Department of Pathology and Laboratory Medicine’s Molecular Diagnostics Laboratory by guiding the analysis and interpretation of germline and somatic testing.

Service Rates

Bioinformatics consultation and analysis services will be billed at $90/hour for FY2023.

Contact Information

For help with your bioinformatics questions, please complete the Quantitative Science Researcher Needs Assessment form and our team will assess your project needs or contact Diana Bahena.