Proposal Preparation

Grant Proposal Basics 

  • Expertise in sponsor guidelines interpretation, budget and application material development, provision of institutional standard information 
  • Final review and authorized submission of all applications for funding on behalf of Lurie Children’s 
  • Work with OSP grant and contract officer to complete internal routing and final application materials, due two (2) business days prior to the sponsor due date 

SPR is required for all direct Federal grant submissions and provides applicants with early advisement from a funded investigator

Please note: The SPR request form is due 8 weeks prior to sponsor deadline 

When is my SPR Request Due? 


OSP staff are available to consult with Principal Investigators (PIs) and staff on the development and submission of their proposal, including: 

  1. Review of Sponsor Guidelines 
  2. Assistance with Budget Development 
  3. Review of Sponsor Forms 

Visit the Budget section for additional information regarding budget preparation. 

OSP staff can provide assistance to PIs and staff in identifying potential funding sources. The OSP office subscribes to several electronic and paper publications with the latest information on potential funding opportunities. 

Additional resources for funding opportunities: 

The PI is required to route each proposal submission using Cayuse SP. The OSP routing form is no longer in use. Proposals with the following items attached are now routed in Cayuse SP: 

  1. Final OSP reviewed budget 
  2. Copy of research proposal (draft copy acceptable) 

Note: Proposal routing using Cayuse SP is required for new submissions, continuation proposals, renewals and transfers. Please note that all proposals submitted through Lurie Children's require routing, including subcontract proposals in which another institution is the prime grantee and a portion of the work will be subcontracted to Lurie Children's. Access Cayuse SP for electronic proposal routing. 

Proposal Submission Guidelines for Subcontract and Consultant Agreements 

NIH Grant Application Resources 

The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the primary Federal agency for conducting and supporting medical research. Composed of 27 Institutes and Centers, the NIH provides leadership and financial support to researchers in every state and throughout the world. 

NIH strives to make their application process as transparent as it can be, providing a number of resources to investigators on the web, including: 

New, Resubmission, and Competing Renewal Applications 

For R01 and R21 applications 

Please contact with any questions related to this document. 

Coming soon...

  • Resource Sharing Guidance 
  • Sample Data Sharing Plan
  • Sample Sharing Model Organisms Plans

Progress Reports (Non-Competing Renewals)

Data Management and Sharing Policy Guidance and Support 

Effective January 25, 2023, the NIH issued a Data Management and Sharing policy (DMSP) to promote the sharing of scientific data. This applies to all research, funded or conducted in whole or in part by the NIH, that results in the generation of scientific data. This includes all NIH-supported research regardless of funding level including:

  • Extramural grants, extramural conracts, intramural research projects and other funding agreements.
  • All competing grant applications submitted for January 25, 2023, and subsequent receipt dates.
  • Proposals submitted on or after January 25, 2023.
  • Other funding agreements that are executed on or after January 25, 2023, unless otherwise stipulated by NIH.

The process to prepare and submit a data management plan involves aspects of grant administration, technical review, and regulatory compliance. Several related offices and groups at Manne Research Institute are available to support researchers through this process. The process will begin by completing a DMSP Request Form. 

The Data Services Core is a service offering from the Quantitative Science pillar at Manne Research Institute that investigators can leverage to support their DMSP related activities, including data management, security and compliance. Visit the Data Services Core page to learn more. 


DMSP resources for investigators including additional guidance, training, templates and DMSP section examples can be found on the Manne Research Institute DMSP Resource Directory.  If you have any questions about this resource, email