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Research Interests

  • Developmental Lung Diseases
  • Genetics of Lung Disease in Infants and Children
  • Consequences of Prematurity
  • Perinatal Origins of Disease

Biography

  • Division Head, Neonatology, Ann & Robert H. Lurie Children’s Hospital of Chicago
  • Raymond & Hazel Speck Berry Board Designated Professorship in Neonatology, Ann & Robert H. Lurie Children’s Hospital of Chicago
  • Professor of Pediatrics (Neonatology), Northwestern University Feinberg School of Medicine

See Lurie Children's Provider Profile

Aaron Hamvas, MD, has a longstanding interest in genetic contributions to lung diseases that affect newborns, children, and adults. Dr. Hamvas has combined his clinical interests in the care of newborn respiratory diseases with an integrated investigative program to understand the modifiable factors that influence outcomes of newborns.

Education and Background

  • Fellowship in Newborn Medicine, Washington University School of Medicine 1987–1990
  • Residency in Pediatrics, St. Louis Children’s Hospital 1981–1984
  • MD, Washington University in St. Louis School of Medicine 1981
  • BS, Rensselaer Polytechnic Institute 1977

Research Highlights

Pathogenic variants in pulmonary surfactant associated genes result in newborn respiratory distress but can also contribute to idiopathic pulmonary fibrosis in adults. Dr. Hamvas and his research team use exome sequencing to identify genes and gene pathways that might inform variability in penetrance of these mutations and provide further insights into the development of chronic lung disease (bronchopulmonary dysplasia) in premature newborns.

 

Dr. Hamvas and his research team are part of an NIH-funded clinical observational study that combines analysis of continuous physiologic data streams, echocardiographic measures, and measures of autonomic nervous system function to identify physiologic perturbations that have an impact on cardiac, respiratory, and neurologic outcomes of premature babies.

Featured Grants

Integrated Analysis of Autonomic Biomarkers in Prematurity-related Ventilatory Control: Determination of Neurorespiratory Maturation and Predictors of Co-morbidity Risk

National Institutes of Health/National Heart, Lung, and Blood Institute
09/01/2016 → 08/31/2022

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Clinical and Community Trials

Research Interests

Autonomic Medicine, Circadian Rhythms, Developmental Neurobiology, Developmental Genetics, Endocrine Genetics, Pacemakers, Respiratory Diseases, Sudden Cardiac Death

Recent Publication

Analysis and comparisons of gene expression changes in patient- derived neurons from ROHHAD, CCHS, and PWS.

Basic and Preclinical Science

Research Interests

Microbiome, Host-Microbial Interactions, Infectious Diseases, Molecular Pathogenesis

Recent Publication

Nasal Dysbiosis in Cutaneous T-Cell Lymphoma Is Characterized by Shifts in Relative Abundances of Non-Staphylococcus Bacteria.

Basic and Preclinical Science

Leena B. Mithal, MD

Mithal (Leena) Laboratory

Research Interests

Perinatal Infections , Neonatal Sepsis , Novel Diagnostics, Placental Inflammation , Early Life Microbiome

Recent Publication

Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes.

Basic and Preclinical Science

Isabelle De Plaen, MD

Principal Investigator

De Plaen Laboratory

Research Interests

Cytokines, Digestive System (Including Gallbladder and Liver), Immunology, Necrotizing Enterocolitis, Neonatal Necrotizing Entercolitis

Recent Publication

Nailfold Capillaroscopy: A Promising, Noninvasive Approach to Predict Retinopathy of Prematurity.

Basic and Preclinical Science

Bria M. Coates, MD

Principal Investigator

Coates Laboratory

Research Interests

Influenza, Respiratory Syncytial Virus, Severe Acute Respiratory Syndrome Coronavirus 2, Innate Immunity, Children, Lung Injury

Recent Publication

NFKB2 haploinsufficiency identified via screening for IFN-α2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications.

Community, Population Health, and Outcomes

Research Interests

Developmental Origins of Childhood Metabolic Disease, Thyroid Cancer in Children and Adolescents, Epigenetics, Maternal/Fetal Nutrition and Metabolism

Recent Publication

Short-Term Complications After Total Thyroidectomy in Children.