SYSTEM OUTAGE: Lurie Children’s continues to respond to a cybersecurity matter. During this time, Stanley Manne Children’s Research Institute continues to conduct research, including recruiting and accepting research participants, collecting data, conducting research procedures, and maintaining research operations. Questions about participation in research, or research in general, may be sent to researchcompliance@luriechildrens.org.

More Information

Ashley S. Plant-Fox, MD

Clinical and Community Trials
Contact: aplant@luriechildrens.org

“When I was a child, two of my cousins were diagnosed and treated for childhood cancer. I know what it feels like to have your family’s life uprooted and shaken by these terrible diseases. We unfortunately experienced the realities of health disparities in the United States and lost one of my cousins to cancer. This drives my passion to discover better and more equitable treatment for childhood cancer. I will spend the entirety of my career researching ways to use the body's own immune system to fight their cancer hopefully leading to more efficacious treatment options and reducing the late effects of our treatment.”

Research Interests

  • Pediatric Neuro-Oncology
  • Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma
  • High Grade Glioma
  • Immunotherapy
  • Targeted Therapies
  • Health Disparities

Biography

  • Attending Physician, Hematology, Oncology, Neuro-Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children’s Hospital of Chicago
  • A.M. Khokhar Research Scholar, Ann & Robert H. Lurie Children’s Hospital of Chicago
  • Associate Professor of Pediatrics (Hematology, Oncology, and Stem Cell Transplantation), Northwestern University Feinberg School of Medicine

See Lurie Children's Provider Profile

Ashley Plant-Fox, MD, specializes in pediatric neuro-oncology and is recognized for her expertise in immunotherapy and the treatment of diffuse intrinsic pontine glioma (DIPG), diffuse midline glioma (DMG), and other high grade gliomas. Dr. Plant-Fox is currently the lead Principal Investigator of an investigator-initiated, early phase clinical trial for rHSC-DIPGVax, a neoantigen specific heat shock protein vaccine, for the treatment of DIPG/DMG. In addition to Ann & Robert H. Lurie Children’s Hospital of Chicago, three other sites are currently enrolling patients on this study: Dana Farber Cancer Institute, Children’s Hospital Orange County, and Alberta Children’s. Dr. Plant-Fox is currently the Lurie Children’s site Principal Investigator for multiple pediatric clinical trial consortiums including PNOC and CONNECT. She also sits on the NCCN pediatric neuro-oncology subcommittee which contributes to national standard practice guidelines for the treatment of high grade glioma. Dr. Plant-Fox dreams of finding a way to use the body’s own immune system to cure aggressive high grade gliomas in children and reduce or eliminate long term effects of current treatments. Dr. Plant-Fox is also passionate about health disparities and working towards the more equitable treatment of patients with pediatric brain tumors.

Education and Background

  • Fellowship in Pediatric Hematology Oncology, Boston Children’s Hospital 2013–2016
  • Residency in Pediatrics, University of Los Angeles California Medical Center 2010–2013
  • MD, Stanford University School of Medicine 2010

Research Highlights

A PHASE I CLINICAL TRIAL PLUS EXPANSION ARM OF RHSC-DIPGVAX PLUS CHECKPOINT BLOCKADE FOR THE TREATMENT OF NEWLY DIAGNOSED DIPG AND DMG

This is a phase I, open label, plus expansion clinical trial evaluating the safety and tolerability of rHSC-DIPGVax in combination with BALSTILIMAB and ZALIFRELIMAB using a 3+3 design for subjects with newly diagnosed DIPG or DMG following completion of radiation therapy. Given this is a first in-human study of rHSC-DIPGVax, an initial study “Lead In” will assess the tolerability of vaccine monotherapy first in older children (12 to 18 years of age) followed by younger children (12 months to 18 years of age).

Sequential Parts A and B of this study will also first enroll patients 12 to 18 years of age before enrolling younger children. The rationale for the combination of vaccine and anti-PD1 therapy includes evidence of a more profound intra-tumoral response with addition of inhibition of negative co-regulatory pathways, such as, PD1/PDL1 and the need to overcome potentially immunosuppressive or immune “cold” microenvironment of gliomas. Anti-CLTA4 therapy will also be combined with rHSC-DIPGVax in the dose escalation portion of this study because of the ability of anti-CTLA4 therapy to induce T cell priming to promote T memory formation. Given the lack of standard treatment options for DIPG and DMG patients, this clinical trial will use combinatorial immunotherapy in upfront treatment of these patients in hopes of maximizing potential efficacy in this at-risk population while still assessing safety throughout.

Part A will evaluate rHSC-DIPGVax plus BALSTILIMAB. Pharmacokinetics (PK) of BALSTILIMAB will also be evaluated to assess exposure. If the rHSC-DIPGVax plus BALSTILIMAB is well tolerated in Part A for 28-days, this study will then move to enrolling Part B to evaluate the safety and tolerability of rHSC-DIPGVax and BALSTILIMAB in combination with ZALIFRELIMAB at two dose levels for a total therapy duration of one year or 27 cycles, whichever occurs first.

Advancement from Part A to Part B and dose escalation in Part B will follow a conservative 3+3 design. The dose limiting toxicity (DLT) monitoring period will last 28 days (2 cycles) for Part A subjects and 42 days (1 cycle) for Part B. Subjects will be allowed to continue in Part A for twenty-seven 14-day cycles or nine 42-day cycles in Part B or 1 year of total therapy, whichever comes first.

After the RP2D of ZALIFRELIMAB is determined, Part C, the expansion arm, will enroll further subjects at this dose level to assess futility versus efficacy. All subjects in trial Part C will be monitored for dose limiting toxicities for the duration of their participation in the study to monitor for excess toxicity.

Featured Grants

A.M. Khokhar Research Scholar

Team Jack Foundation Grant

PCRF–Will Irwin Family Foundation Research Scholar

Similar Researchers

Community, Population Health, and Outcomes

Research Interests

Health Policy, Healthcare Quality, Health Disparities, Outcome Measures

Recent Publication

Translating the Value of the Academic Surgeon Into Salary, Time, and Resources.

Basic and Preclinical Science

Research Interests

Microbiome, Host-Microbial Interactions, Infectious Diseases, Molecular Pathogenesis

Recent Publication

Nasal Dysbiosis in Cutaneous T-Cell Lymphoma Is Characterized by Shifts in Relative Abundances of Non-Staphylococcus Bacteria.

Clinical and Community Trials

Research Interests

Sports Injury Prevention, Concussion, Sports Specialization

Recent Publication

Rhythmic gymnasts' injuries in a pediatric sports medicine clinic in the United States: a 10-year retrospective chart review.

Clinical and Community Trials

Research Interests

Pediatric Respiratory Infections, Pediatric Emergency Medicine, Clinical and Molecular Epidemiology, Antimicrobial Stewardship, Predictive Analytics

Recent Publication

Liver transaminase concentrations in children with acute SARS-CoV-2 infection.

Basic and Preclinical Science

Leena B. Mithal, MD

Mithal (Leena) Laboratory

Research Interests

Perinatal Infections , Neonatal Sepsis , Novel Diagnostics, Placental Inflammation , Early Life Microbiome

Recent Publication

Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes.

Basic and Preclinical Science

Isabelle De Plaen, MD

Principal Investigator

De Plaen Laboratory

Research Interests

Cytokines, Digestive System (Including Gallbladder and Liver), Immunology, Necrotizing Enterocolitis, Neonatal Necrotizing Entercolitis

Recent Publication

Nailfold Capillaroscopy: A Promising, Noninvasive Approach to Predict Retinopathy of Prematurity.