Debra E. Weese-Mayer, MD

Clinical and Community Trials
Contact: DWeese-Mayer@LurieChildrens.org

“For my entire professional career, I have focused on researching disorders of respiratory control and autonomic regulation, primarily congenital central hypoventilation syndrome; rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation; Rett syndrome; familial dysautonomia, and sudden infant death syndrome, with a more recent focus on autonomic maturation in preterm infants.”

Research Interests

  • Autonomic Medicine
  • Circadian Rhythms
  • Developmental Neurobiology
  • Developmental Genetics
  • Endocrine Genetics
  • Pacemakers
  • Respiratory Diseases
  • Sudden Cardiac Death

Biography

  • Chief, Center for Autonomic Medicine in Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago
  • Professor of Pediatrics (Critical Care), Northwestern University Feinberg School of Medicine
  • Beatrice Cummings Mayer Professor in Pediatric Autonomic Medicine, Northwestern University Feinberg School of Medicine

See Lurie Children's Provider Profile

Sustained focus in rare respiratory control and autonomic disorders of infancy, childhood, and adulthood (RADICA), including congenital central hypoventilation syndrome (CCHS), rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD), Rett syndrome, and familial dysautonomia, led to Dr. Debra Weese-Mayer’s position as Chief of the Division of Pediatric Autonomic Medicine at Ann & Robert H. Lurie Children’s Hospital of Chicago and Stanley Manne Children’s Research Institute. With more than 35 years of clinical and research experience in RADICA, development of this emerging discipline was the natural progression to integrate expertise in all systems impacted by the autonomic nervous system, develop an armamentarium of non-invasive child-friendly objective physiologic measures of autonomic nervous system (dys)regulation, build physiologic and disease-specific RADICA databases including expansion of the longitudinal CCHS and ROHHAD NIH.gov REDCap Registries, embed basic scientists in clinical programs to add depth to longitudinal physiologic in-hospital and ambulatory wireless wearable measures in rare disorders as well as more common conditions, utilize the NIH Toolbox paired with wireless wearable technology of vital sign measures to identify autonomic antecedents of neurodevelopmental impairment in CCHS, ROHHAD, and infants born extremely prematurely, and develop the next generation of RADICA physicians and scientists.

Education and Background

  • Fellowship in Neonatal-perinatal Medicine and Control of Breathing, Children’s Memorial Hospital 1982-1986
  • Residency in Pediatrics, Children’s Memorial Hospital 1978-1981
  • MD, University of Chicago, Pritzker School of Medicine 1978

Research Highlights

INTEGRATED ANALYSIS OF AUTONOMIC BIOMARKERS IN PREMATURITY-RELATED VENTILATORY CONTROL: DETERMINATION OF NEURORESIRATORY MATURATION AND PREDICTORS OF CO-MORBIDITY RISK


EVALUATING THE INTEGRATION OF CARDIOVASCULAR, RESPIRATORY, AND CEREBROVASCULAR STABILITY AND MATURATION AND THEIR EFFECT ON RESPIRATORY AND NEUROLOGIC MORBIDITY IN PRETERM INFANTS


POST-VENT, THE SEQUELAE: PERSONALIZED PROGNOSTIC MODELING FOR CONSEQUENCES OF NEONATAL INTERMITTENT HYPOXEMIA IN PRETERM INFANTS AT PRE-SCHOOL AGE


PHOX2B CONGENITAL CENTRAL HYPOVENTILATION SYNDROME: PHYSIOLOGIC SIGNATURES FOR CLINICAL TRIALS READINESS

 

ROHHAD: DENTAL PULP STEM CELL MODELS TO INVESTIGATE CAUSES AND CONSEQUENCES

Featured Grants

Integrated Analysis of Autonomic Biomarkers in Prematurity- Related Ventilatory Control: Determination of Neurorespiratory Maturation and Predictors of Co-morbidity Risk

National Heart, Lung, and Blood Institute
09/01/2016 → 06/30/2022

ROHHAD: Dental Pulp Stem Cell Models to Investigate Causes and Consequences

ROHHAD Association (Scotland)
11/01/2019 → 12/31/2022

Evaluating the Integration of Cardiovascular, Respiratory, and Cerebrovascular Stability and Maturation and Their Effect on Respiratory and Neurologic Morbidity in Preterm Infants

National Heart, Lung, and Blood Institute
09/05/2020 → 06/30/2022

Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

National Heart, Lung, and Blood Institute
12/15/2021 → 11/30/2026

Similar Researchers

Basic and Preclinical Science

Research Interests

Developmental Lung Diseases, Genetics of Lung Disease in Infants and Children, Consequences of Prematurity, Perinatal Origins of Disease

Recent Publication

Cardiorespiratory Monitoring Data to Predict Respiratory Outcomes in Extremely Preterm Infants.

Basic and Preclinical Science

Research Interests

Microbiome, Host-Microbial Interactions, Infectious Diseases, Molecular Pathogenesis

Recent Publication

Nasal Dysbiosis in Cutaneous T-Cell Lymphoma Is Characterized by Shifts in Relative Abundances of Non-Staphylococcus Bacteria.

Clinical and Community Trials

Research Interests

Pediatric Respiratory Infections, Pediatric Emergency Medicine, Clinical and Molecular Epidemiology, Antimicrobial Stewardship, Predictive Analytics

Recent Publication

Liver transaminase concentrations in children with acute SARS-CoV-2 infection.

Basic and Preclinical Science

Youyang Zhao, PhD

Zhao Laboratory
Basic and Preclinical Science

Leena B. Mithal, MD

Mithal (Leena) Laboratory

Research Interests

Perinatal Infections , Neonatal Sepsis , Novel Diagnostics, Placental Inflammation , Early Life Microbiome

Recent Publication

Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes.

Clinical and Community Trials

Research Interests

Sports Injury Prevention, Concussion, Sports Specialization

Recent Publication

Rhythmic gymnasts' injuries in a pediatric sports medicine clinic in the United States: a 10-year retrospective chart review.