Joshua B. Ewen, MD

Clinical and Community Trials
Pronouns: he, him, his
Contact: jewen@luriechildrens.org

“I want to do good science, help figure out how the brain works, and help kids with disabilities.”

Research Interests

  • Cognition in Developmental Disabilities (Autism, ADHD)
  • Epilepsy
  • Brain-Behavior Relationships
  • Theory-Based Psychology
  • Motor Control
  • Biomarker Validation

Biography

  • Division Head, Developmental and Behavioral Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago
  • Irene Heinz Given and John La Porte Given Research Professorship in Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago

See Lurie Children's Provider Profile

Joshua Ewen, MD, is a pediatric neurologist, neurodevelopmental specialist, and clinical neurophysiologist. He serves as Division Head of Developmental-Behavioral Pediatrics. His research has been focused primarily on the borderlands between sensory-motor function and cognition in autism and ADHD, but his is lab is also interested in theory-based data integration in psychology and in biomarker validation methodology.

Education and Background

  • Fellowship in clinical neurophysiology, Johns Hopkins Hospital 2006–2007
  • Residency in neurodevelopmental disabilities, Johns Hopkins Hospital 2002–2006
  • Residency in pediatrics, Cincinnati Children’s Hospital Medical Center 2000–2002
  • MD, Tulane University School of Medicine 2000

Research Highlights

CAUSAL ANALYSIS OF EVIDENCE FOR THEORIES OF AUTISM

Science consists of many different studies, yet we need to integrate information together to really understand answers to complex questions, like which features of autism cause other features of autism. We employ large data sources, formalization of psychological theories as graphs and causal-inference statistical analysis to evaluate evidence for a variety of theories of autism.

REPETITIVE TMS TREATMENTS FOR ADHD

This work builds on decades of research understanding the neurobiology of ADHD. It involves novel approaches to targeting repetitive TMS brain stimulation to mitigate the symptoms of ADHD.

REPORTING GUIDELINES FOR EEG-BASED BIOMARKER VALIDATION STUDIES

Biomarkers based on EEG are expected to help diagnosis and monitoring in developmental, psychiatric,
and other neurological conditions. A group of experts convened under IFCN is identifying the important
elements of information needed to prove rigorously that these biomarkers perform as intended and can
be relied upon in clinical care and in clinical trials.

Featured Grants

ADHD PreSMART: ADHD PreSMA Response inhibition Therapy

National Institutes of Health/National Institute of Mental Health

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Microbiome, Host-microbial interactions, Infectious diseases, Molecular pathogenesis

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Gut microbiota analyses of cutaneous T-cell lymphoma patients undergoing narrowband ultraviolet B therapy reveal alterations associated with disease treatment.

Clinical and Community Trials

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Genetics, Genomic Medicine, Metabolism (Inborn Errors of Metabolism), Gene Therapy, Biomarkers, RASopathies, Neurofibromatosis, Lysosomal Storage Diseases, Gene Discovery, Clinical Trials

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Role of CAMK2D in neurodevelopment and associated conditions.

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Pediatric Respiratory Infections, Pediatric Emergency Medicine, Clinical and Molecular Epidemiology, Antimicrobial Stewardship, Predictive Analytics

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Household Transmission Dynamics of Asymptomatic SARS-CoV-2-Infected Children: A Multinational, Controlled Case-Ascertained Prospective Study.

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Leena B. Mithal, MD

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Perinatal Infections , Neonatal Sepsis , Novel Diagnostics, Placental Inflammation , Early Life Microbiome

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Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes.

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Critical care nephrology, Extracorporeal support, Blood purification, Critical care education, Industry partnerships, Chronic critical illness, Pediatric and community partnership, Career development, Leadership

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External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock.

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Pediatric Neuro-Oncology, Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma, High Grade Glioma, Immunotherapy, Targeted Therapies, Health Disparities

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An international study evaluating the epidemiology of intracranial germ cell tumors in the native versus immigrant Japanese populations: the need for an international registry.