SYSTEM OUTAGE: Lurie Children’s continues to respond to a cybersecurity matter. During this time, Stanley Manne Children’s Research Institute continues to conduct research, including recruiting and accepting research participants, collecting data, conducting research procedures, and maintaining research operations. Questions about participation in research, or research in general, may be sent to

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Research Interests

  • Family-centered Care
  • Gender Disparities in the Workforce
  • Continuity of Care
  • Transitions of Care for Infants with Medical Complexities


  • Associate Professor of Pediatrics (Neonatology), Northwestern University Feinberg School of Medicine
  • Attending Physician, Neonatology, Ann & Robert H. Lurie Children’s Hospital of Chicago

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Education and Background

  • Fellowship in Neonatology, Children’s Memorial Hospital 2007-2010
  • Residency in Pediatrics, University of Chicago Comer Children’s Hospital 2004-2007
  • MD, University of Illinois College of Medicine 2004

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Recent Publication

Subcutaneous fat necrosis of the newborn: A retrospective study of 32 infants and care algorithm.

Research Interests

Racial and Ethnic Health Disparities (particularly as it pertains to patients with cystic fibrosis)

Recent Publication

The upper airway microbiome in Hispanic children with cystic fibrosis.

Recent Publication

Hyperinflation and its association with successful transition to home ventilator devices in infants with chronic respiratory failure and severe bronchopulmonary dysplasia.

Basic and Preclinical Science
Basic and Preclinical Science

Isabelle De Plaen, MD

Principal Investigator

De Plaen Laboratory

Research Interests

Cytokines, Digestive System (Including Gallbladder and Liver), Immunology, Necrotizing Enterocolitis, Neonatal Necrotizing Entercolitis

Recent Publication

Nailfold Capillaroscopy: A Promising, Noninvasive Approach to Predict Retinopathy of Prematurity.

Clinical and Community Trials

Research Interests

Autonomic Medicine, Circadian Rhythms, Developmental Neurobiology, Developmental Genetics, Endocrine Genetics, Pacemakers, Respiratory Diseases, Sudden Cardiac Death

Recent Publication

Analysis and comparisons of gene expression changes in patient- derived neurons from ROHHAD, CCHS, and PWS.