Biography
- Attending Physician, Hematology, Oncology, Neuro-Oncology, and Stem Cell Transplantation, Ann & Robert H. Lurie Children’s Hospital of Chicago
- Sharon B. Murphy, MD and Steven T. Rosen, MD Research Professorship in Cancer Biology & Chemotherapy, Ann & Robert H. Lurie Children’s Hospital of Chicago
- Assistant Professor of Pediatrics (Hematology, Oncology, and Stem Cell Transplantation), Northwestern University Feinberg School of Medicine
See Lurie Children's Provider Profile
Education and Background
- Fellowship in Pediatric Hematology, Oncology, Stem Cell Transplantation, Ann & Robert H. Lurie Children’s Hospital of Chicago 2017-2020
- Residency in Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago 2014-2017
- MD, University of Washington School of Medicine 2014
- PhD, University of Washington School of Medicine 2011
Research Highlights
NUCLEAR ORGANIZATION IN THE PEDIATRIC TUMOR RHABDOMYOSARCOMA
The purpose of this project is to characterize differences and similarities of the organization of the cell nucleus between rhabdomyosarcoma tumor cells and normal skeletal muscle cells with the aim of identifying differences that are key to tumor biology. Organization in the nucleus of genes and chromosomes has impacts on cell behavior and gene expression, but the role that plays in pediatric cancers such as rhabdomyosarcoma is not entirely clear. Using tools such as molecular biology techniques, three dimensional microscopy, and next-generation sequencing, Dr. MacQuarrie and the research team are probing what specific differences are present, with the hope such differences will help explain rhabdomyosarcoma behavior and growth and present novel avenues to pursue for future treatment.
Featured Grants
Genomic and Nuclear Organizational Changes in Chemotherapy-Resistant Rhabdomyosarcoma Cells
Alex’s Lemonade Stand Foundation
02/01/2024 → 02/29/2028
Biological Consequences of Altered Chromosomal Organization in Rhabdomyosarcoma Cells
CURE Childhood Cancer Early Investigator Award
07/01/2023 → 06/30/2025
Nuclear Organization in the Pediatric Tumor Rhabdomyosarcoma
Hyundai Hope on Wheels Hope Scholar Award
12/31/2021 → 12/31/2023
Nuclear Organization in the Pediatric Tumor Rhabdomyosarcoma
Northwestern University Clinical and Translational Sciences KL2 Scholar Award
09/01/2021 → 08/31/2023
