Kyle L. MacQuarrie, MD, PhD

Basic and Preclinical Science
Molecular and Translational Cancer Biology
MacQuarrie Laboratory
Pronouns: He, Him, His
Contact: kmacquarrie@luriechildrens.org

“We’ve seen 50 years of improvement in the care of pediatric cancer patients, much of that thanks to scientific discoveries and advances. I aim to produce science that will contribute in a meaningful way to the next 50 years.”

Research Interests

  • Pediatric Solid Tumors
  • Pediatric Sarcomas
  • Developmental Biology
  • Nuclear Organization

Biography

  • Attending Physician, Hematology, Oncology, Neuro-Oncology, and Stem Cell Transplantation, Ann & Robert H. Lurie Children’s Hospital of Chicago
  • Sharon B. Murphy, MD and Steven T. Rosen, MD Research Professorship in Cancer Biology & Chemotherapy, Ann & Robert H. Lurie Children’s Hospital of Chicago 
  • Instructor of Pediatrics (Hematology, Oncology, and Stem Cell Transplantation), Northwestern University Feinberg School of Medicine

See Lurie Children's Provider Profile

Education and Background

  • Fellowship in Pediatric Hematology, Oncology, Stem Cell Transplantation, Ann & Robert H. Lurie Children’s Hospital of Chicago 2017-2020
  • Residency in Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago 2014-2017
  • MD, University of Washington School of Medicine 2014
  • PhD, University of Washington School of Medicine 2011

Research Highlights

NUCLEAR ORGANIZATION IN THE PEDIATRIC TUMOR RHABDOMYOSARCOMA 

The purpose of this project is to characterize differences and similarities of the organization of the cell nucleus between rhabdomyosarcoma tumor cells and normal skeletal muscle cells with the aim of identifying differences that are key to tumor biology. Organization in the nucleus of genes and chromosomes has impacts on cell behavior and gene expression, but the role that plays in pediatric cancers such as rhabdomyosarcoma is not entirely clear. Using tools such as molecular biology techniques, three dimensional microscopy, and next-generation sequencing, Dr. MacQuarrie and the research team are probing what specific differences are present, with the hope such differences will help explain rhabdomyosarcoma behavior and growth and present novel avenues to pursue for future treatment. 

Featured Grants

Biological Consequences of Altered Chromosomal Organization in Rhabdomyosarcoma Cells

CURE Childhood Cancer Early Investigator Award
07/01/2023 → 06/30/2025

Nuclear Organization in the Pediatric Tumor Rhabdomyosarcoma

Hyundai Hope on Wheels Hope Scholar Award
12/31/2021 → 12/31/2023

Nuclear Organization in the Pediatric Tumor Rhabdomyosarcoma

Northwestern University Clinical and Translational Sciences KL2 Scholar Award
09/01/2021 → 08/31/2023

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Developmental Origins of Disease, Epigenetics, Maternal/Fetal Nutrition and Metabolism, Endocrine Genetics, Thyroid Nodules and Cancer

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Long‐term Follow Up of Children with in utero Exposure to Sulfonylurea Medications

Basic and Preclinical Science

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Microbiome, Host-Microbial Interactions, Infectious Diseases, Molecular Pathogenesis

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Screening Students and Staff for Asymptomatic Coronavirus Disease 2019 in Chicago Schools.

Clinical and Community Trials

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Pediatric Neuro-Oncology, Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma, High Grade Glioma, Immunotherapy, Targeted Therapies, Health Disparities

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Monica M. Laronda, PhD

Laronda Laboratory

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Regenerative Medicine, Human Induced Pluripotent Stem Cells, Ovarian Biology, Gonadal Sex Determination, Sex Hormones, Fertility

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Building Organs Using Tissue-Specific Microenvironments: Perspectives from a Bioprosthetic Ovary.

Clinical and Community Trials

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Neuroblastoma, Pediatric Solid Tumors, Pharmacogenomics, Developmental Therapeutics

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Age, Diagnostic Category, Tumor Grade, and Mitosis-Karyorrhexis Index Are Independently Prognostic in Neuroblastoma: An INRG Project

Community, Population Health, and Outcomes

Research Interests

Health Policy, Healthcare Quality, Health Disparities, Outcome Measures