Kyle L. MacQuarrie, MD, PhD

Basic and Preclinical Science
Molecular and Translational Cancer Biology
MacQuarrie Laboratory
Pronouns: He, Him, His
Contact: kmacquarrie@luriechildrens.org

“We’ve seen 50 years of improvement in the care of pediatric cancer patients, much of that thanks to scientific discoveries and advances. I aim to produce science that will contribute in a meaningful way to the next 50 years.”

Research Interests

  • Pediatric Solid Tumors
  • Pediatric Sarcomas
  • Developmental Biology
  • Nuclear Organization

Biography

  • Attending Physician, Hematology, Oncology, Neuro-Oncology, and Stem Cell Transplantation, Ann & Robert H. Lurie Children’s Hospital of Chicago
  • Sharon B. Murphy, MD and Steven T. Rosen, MD Research Professorship in Cancer Biology & Chemotherapy, Ann & Robert H. Lurie Children’s Hospital of Chicago 
  • Assistant Professor of Pediatrics (Hematology, Oncology, and Stem Cell Transplantation), Northwestern University Feinberg School of Medicine

See Lurie Children's Provider Profile

Education and Background

  • Fellowship in Pediatric Hematology, Oncology, Stem Cell Transplantation, Ann & Robert H. Lurie Children’s Hospital of Chicago 2017-2020
  • Residency in Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago 2014-2017
  • MD, University of Washington School of Medicine 2014
  • PhD, University of Washington School of Medicine 2011

Research Highlights

NUCLEAR ORGANIZATION IN THE PEDIATRIC TUMOR RHABDOMYOSARCOMA 

The purpose of this project is to characterize differences and similarities of the organization of the cell nucleus between rhabdomyosarcoma tumor cells and normal skeletal muscle cells with the aim of identifying differences that are key to tumor biology. Organization in the nucleus of genes and chromosomes has impacts on cell behavior and gene expression, but the role that plays in pediatric cancers such as rhabdomyosarcoma is not entirely clear. Using tools such as molecular biology techniques, three dimensional microscopy, and next-generation sequencing, Dr. MacQuarrie and the research team are probing what specific differences are present, with the hope such differences will help explain rhabdomyosarcoma behavior and growth and present novel avenues to pursue for future treatment. 

Featured Grants

Genomic and Nuclear Organizational Changes in Chemotherapy-Resistant Rhabdomyosarcoma Cells

Alex’s Lemonade Stand Foundation
02/01/2024 → 02/29/2028

Biological Consequences of Altered Chromosomal Organization in Rhabdomyosarcoma Cells

CURE Childhood Cancer Early Investigator Award
07/01/2023 → 06/30/2025

Nuclear Organization in the Pediatric Tumor Rhabdomyosarcoma

Hyundai Hope on Wheels Hope Scholar Award
12/31/2021 → 12/31/2023

Nuclear Organization in the Pediatric Tumor Rhabdomyosarcoma

Northwestern University Clinical and Translational Sciences KL2 Scholar Award
09/01/2021 → 08/31/2023

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Developmental Origins of Childhood Metabolic Disease, Thyroid Cancer in Children and Adolescents, Epigenetics, Maternal/Fetal Nutrition and Metabolism

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Short-Term Complications After Total Thyroidectomy in Children.

Basic and Preclinical Science

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Microbiome, Host-Microbial Interactions, Infectious Diseases, Molecular Pathogenesis

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Gut dysbiosis in cutaneous T-cell lymphoma is characterized by shifts in relative abundances of specific bacterial taxa and decreased diversity in more advanced disease.

Clinical and Community Trials

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Pediatric Neuro-Oncology, Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma, High Grade Glioma, Immunotherapy, Targeted Therapies, Health Disparities

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Recurrent pediatric infratentorial ependymomas: a systematic review and meta-analysis on outcomes and molecular classification.

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Regenerative Medicine, Human Induced Pluripotent Stem Cells, Ovarian Biology, Gonadal Sex Determination, Sex Hormones, Fertility

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Workflow for Management of Gonadal Neoplasm in Two Patients with Differences of Sex Development Enrolled in an Experimental Gonadal Tissue Cryopreservation Protocol.

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Sports Injury Prevention, Concussion, Sports Specialization

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Rhythmic gymnasts' injuries in a pediatric sports medicine clinic in the United States: a 10-year retrospective chart review.

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Neuroblastoma, Pediatric Solid Tumors, Pharmacogenomics, Developmental Therapeutics

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Transitional care and clinical management of adolescents, young adults, and suspected new adult patients with congenital central hypoventilation syndrome.