Patrick C. Seed, MD, PhD, FIDSA

Basic and Preclinical Science
Clinical and Community Trials
Quantitative Science
Host-Microbial Interactions, Inflammation, and Immunity
Seed Laboratory
Pronouns: He, Him, His
Contact: pseed@luriechildrens.org

“Through my research, I'm looking to understand how microbes that cover our bodies inside and out influence health such as in obesity, asthma, and pneumonia. I look at every problem through the lens of finding innovative ways to turn discoveries into diagnostics and therapeutics that will ultimately create healthier futures for children everywhere.”

Research Interests

  • Microbiome
  • Host-Microbial Interactions
  • Infectious Diseases
  • Molecular Pathogenesis

Biography

  • President and Chief Research Officer, Stanley Manne Children’s Research Institute
  • Attending Physician, Infectious Disease, Ann & Robert H. Lurie Children’s Hospital of Chicago
  • Children’s Research Fund Chair in Basic Science
  • Professor of Pediatrics (Infectious Diseases) and Microbiology­Immunology, Northwestern University Feinberg School of Medicine

See Lurie Children's Provider Profile

Patrick C. Seed, MD, PhD, is President and Chief Research Officer at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago. He is a Professor of Pediatrics and Microbiology–Immunology at Northwestern University Feinberg School of Medicine. In addition, he is an Attending Physician in the Division of Pediatric Infectious Diseases in the Department of Pediatrics and Past Division Head. Dr. Seed's lab aims to translate molecular knowledge of microbial/microbiome genetics, physiology, and pathogenesis into diagnostics and treatments for a broad range of pediatric diseases. The Seed Research Team combines human clinical studies, conventional and germ-free models, molecular genetics, immunology, biochemistry, structural biology, high-dimensional data computational analysis, and complementary 'omics technologies including genomics, metagenomics, transcriptomics, metatranscriptomics, and metabolomics to understand complex systems. The lessons learned from these molecular studies are used to design new diagnostics and therapeutics.

Education and Background

  • Fellowship, Washington University School of Medicine 2005
  • Chief Resident, University of Michigan School of Medicine 2002
  • Residency, University of Michigan School of Medicine 2001
  • MD, University of Rochester, School of Medicine 1998
  • PhD, University of Rochester 1996
  • BS, Bowdoin College 1990

Research Highlights

THE ROLE OF CORYNEBACTERIUM SPECIES IN RESPIRATORY HEALTH

In this project, we dissect the pangenome of the genus Corynebacterium and use molecular biology, cellular assays , and animal models to identify the mechanisms through which Corynebacterium spp. compete with other respiratory bacteria and alter the host response to inflammation and infection. Bacterial pneumonia remains one of the leading global causes of death among young children. The respiratory microbiota is hypothesized as a mediator of respiratory health and exclusion of bacterial pneumonia pathogens.

We and others previously mapped the infant nasopharyngeal microbiota and identified an inverse relationship between the presence of Corynebacterium spp. and respiratory pathogens such as Streptococcus pneumoniae. However, Corynebacterium spp. remain poorly understood and their mechanisms of interacting with the host and other microbes is poorly described. In collaboration with Dr. Matthew Kelly, we have assembled a growing sample collection from the human nasopharynx and culture collection including diverse corynebacteria. Using a combination of genomics, metagenomics, transcriptomics, respiratory cell culture models, molecular genetics, biochemistry, and murine models, we are identifying the diverse mechanisms through which Corynebacterium spp. attach and engage host epithelial cells, augment immune and inflammatory responses, and directly and indirectly inhibit other respiratory organisms including pneumonia pathogens.

THE PEDIATRIC OBESITY MICROBIOME & METABOLISM STUDY (POMMS)

In collaboration with investigators at Duke University, we are investigating the childhood and adolescent gut microbiome and its relationship to pediatric overweight and obesity. We predicted that children with obesity have different microbiota and metabolic signatures than healthy weight children and adults with obesity.

We conducted a prospective, longitudinal study of over 300 youth, performing marker gene and shotgun metagenomics and metabolomic profiling. We are conducting integrative data modelling to determine the relationship between clinical measures, microbiome, and metabolic factors. We are conducting model system studies to identify causal relationships between microbial communities, metabolic states, and mechanistic pathways to corroborate the human associative studies. Together, we seek to understand how the earlier stages of obesity and metabolic plasticity are established prior to the development of fixed, late stage adult disease. Insights into the early disease stages may inform effective interventions to alter and reverse the obesity and associated metabolic disturbances.

FOOD ALLERGY OUTCOMES RELATED TO WHITE AND AFRICAN AMERICAN RACIAL DIFFERENCES (FORWARD)

In collaboration with Dr. Ruchi Gupta and the Center for Food Allergy and Asthma Research at Northwestern University, we are using shotgun metagenomics and high dimensional data analysis to identify differences in microbiome composition by racial identify among children with food allergies. With rich clinical, social, nutritional, and environmental data and serial fecal samples. the study will find correlates between food allergy type, severity, race, and clinical parameters.

Featured Grants

Targeting the Meta-organismal Butyrate Pathway to Prevent Arterial Restenosis after Vascular Surgery

NHLBI
04/01/2021 → 03/31/2026

Successful Clinical Response in Pneumonia Therapy (SCRIPT) Systems Biology Center

NIAID
01/01/2017 → 12/31/2022

Surveillance, Transmission Dynamics, and Disparities of COVID-19 among Chicago Children

Walder Foundation
10/01/2020 → 09/30/2022

A Comprehensive Research Resource to Define Mechanisms Underlying Microbial Regulation of Host Metabolism in Pediatric Obesity and Obesity Targeted Therapeutics

NIDDK
09/25/2016 → 08/31/2022

Food Allergy Outcomes Related to White and African American Racial Differences (FORWARD)

NIAID
05/11/2017 → 04/30/2022

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Clinical and Community Trials

Research Interests

Critical Care, Viral Respiratory Infections, Lung Injury and Repair, Immune Regulation

Recent Publication

Age-related Differences in the Nasal Mucosal Immune Response to SARS-CoV-2.

Clinical and Community Trials

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Interventricular Mechanics, Right Ventricular Failure, Role of Immunologic Phenotype on Post-heart Transplant Outcomes, Post-heart Transplant Kidney Injury and Failure

Clinical and Community Trials
Clinical and Community Trials