Biography
- Division Head, Critical Care Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago
- Posy and John Krehbiel Professorship in Critical Care Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago
- Professor of Pediatrics, Northwestern University Feinberg School of Medicine
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After receiving his medical degree from Indiana University Medical School, Dr. Basu completed his residency in pediatrics and then a fellowship in pediatric critical care at Children's Memorial Hospital. He subsequently began his faculty career at Cincinnati Children’s Hospital and Medical Center as a Clinical Instructor in Pediatrics and advanced to Associate Professor, serving over time as the Co-Director for the Center for Acute Care Nephrology and Associate Fellowship Program Director. In 2017 he joined the Children’s Hospital of Atlanta and Emory University School of Medicine, where he served as Research Director of Critical Care Medicine and was a lead pediatric clinician investigator (including serving as a lead during the COVID scientific response in pediatrics)—bringing CHOA into numerous large center trials and industry sponsored work.
Dr. Basu is internationally recognized for his research and is considered a world expert in the study of acute kidney injury among critically ill patients. His work encompasses tools for risk stratification, biomarker based phenotyping of acute kidney injury, advanced extracorporeal renal support therapies, and novel strategies for fluid management. He has published more than 150 peer-reviewed original science papers, review articles and book chapters. His research portfolio spans across basic, translational, clinical, education, and simulation science with support from local programs, federal grants, and industry. He serves on the editorial board of several critical care and nephrology journals and on several international consensus panels for critical care nephrology. He serves on the executive board of the Pediatric AKI NEXUS (otherwise known as the Prospective Pediatric AKI Registry) and also serves in prominent leadership roles in the Society for Critical Care Medicine. In addition to being the Founder and Director of the GUARDIANS program, beginning in 2022, he is the Chair of the Pediatric Section of the Society for Critical Care Medicine.
Education and Background
- Northwestern University School of Continuing Studies 2015
- Fellowship in critical care medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago 2006-2009
- Residency in pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago 2003-2006
- MD, Indiana University School of Medicine 2003
Research Highlights
Epidemiology of AKI in Children and Young Adults - The AWARE study
Epidemiology of AKI in Children and Young Adults - The AWARE study - published in The New England Journal of Medicine (2017) was the largest to date multinational, multi-ICU epidemiologic survey of AKI in pediatrics - identifying AKI in 1 in 4 critically ill patients and independently associated with worsened outcome. This study has been cited nearly 1000 times and is the primary/cornerstone paper in pediatric AKI.
The Derivation and Validation of the Renal Angina Index - RAI - for AKI Risk Prognostication
The Derivation and Validation of the Renal Angina Index - RAI - for AKI Risk Prognostication - was initially published in 2014 and has now been validated in nearly 25000 children and 10000 adults with critical illness. The easy to calculate bedside score separates patients at highest and lowest risk for severe, persistent AKI 3 days after calculation (12 hours into ICU course). The initial integration of the RAI into a clinical pathway for fluid regulation resulted in decreased time to renal replacement therapy initiation, reduced overall time of RRT, reduced ICU length of stay, greater survival, and greater dialysis free survival. Analyses of RAI has been published in the Lancet, JAMA, JASN, CJASN, NDT, PCCM, CCM and other major medical journals.
"Acute Disease Quality Initiatives" ADQI Consensus Meeting
The first ever pediatric focused "Acute Disease Quality Initiatives" ADQI Consensus meeting to prioritize work (including clinical care, education, advocacy, and research) needed to be completed was executed in November of 2021 and published in JAMA Network Open in Dec 2022.
