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Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy

Yu Kanemaru, Manabu Natsumeda, Masayasu Okada, Rie Saito, Daiki Kobayashi, Takeyoshi Eda, Jun Watanabe, Shoji Saito, Yoshihiro Tsukamoto, Makoto Oishi, Hirotake Saito, Masayuki Nagahashi, Takahiro Sasaki, Rintaro Hashizume, Hidefumi Aoyama, Toshifumi Wakai, Akiyoshi Kakita, Yukihiko Fujii

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Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy

Emmanuelle Huillard, Rintaro Hashizume, Joanna J Phillips, Amélie Griveau, Rebecca A Ihrie, Yasuyuki Aoki, Theodore Nicolaides, Arie Perry, Todd Waldman, Martin McMahon, William A Weiss, Claudia Petritsch, C David James, David H Rowitch

Publication

Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer.

A Grothey, R Hashizume, A A Sahin, P D McCrea

Publication

Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies

Eleonore Maury, Rintaro Hashizume

Publication

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.

Kui-Ming Chan, Dong Fang, Haiyun Gan, Rintaro Hashizume, Chuanhe Yu, Mark Schroeder, Nalin Gupta, Sabine Mueller, C David James, Robert Jenkins, Jann Sarkaria, Zhiguo Zhang

Publication

Systemic and local drug delivery for treating diseases of the central nervous system in rodent models.

Laura Serwer, Rintaro Hashizume, Tomoko Ozawa, C David James

Publication

MeLK inhibition in diffuse intrinsic pontine glioma

Michaël H Meel, Mark C de Gooijer, Miriam Guillén Navarro, Piotr Waranecki, Marjolein Breur, Levi C M Buil, Laurine E Wedekind, Jos W R Twisk, Jan Koster, Rintaro Hashizume, Eric H Raabe, Angel Montero Carcaboso, Marianna Bugiani, Olaf van Tellingen, Dannis G van Vuurden, Gertjan J L Kaspers, Esther Hulleman

Publication

Bioluminescence Imaging of an Immunocompetent Animal Model for Glioblastoma

Aaron J Clark, Shayan Fakurnejad, Quanhong Ma, Rintaro Hashizume

Publication

Combined BRAF V600E and MEK blockade for BRAF V600E -mutant gliomas

Jie Zhang, Tsun-Wen Yao, Rintaro Hashizume, Sujatmi Hariono, Krister J Barkovich, Qi-Wen Fan, Michael Prados, C David James, William A Weiss, Theodore Nicolaides

Publication

DNA methylation profiling to predict recurrence risk in meningioma: Development and validation of a nomogram to optimize clinical management

Farshad Nassiri, Yasin Mamatjan, Suganth Suppiah, Jetan H Badhiwala, Sheila Mansouri, Shirin Karimi, Olli Saarela, Laila Poisson, Irina Gepfner-Tuma, Jens Schittenhelm, Ho-Keung Ng, Houtan Noushmehr, Patrick Harter, Peter Baumgarten, Michael Weller, Matthias Preusser, Christel Herold-Mende, Marcos Tatagiba, Ghazaleh Tabatabai, Felix Sahm, Andreas von Deimling, Gelareh Zadeh, Kenneth D Aldape

Publication

Stable luciferase expression does not alter immunologic or in vivo growth properties of GL261 murine glioma cells

Aaron J Clark, Michael Safaee, Taemin Oh, Michael E Ivan, Vamsi Parimi, Rintaro Hashizume, Tomoko Ozawa, Charles D James, Orin Bloch, Andrew T Parsa

Publication

Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells.

Robin G Lerner, Stefan Grossauer, Banafsheh Kadkhodaei, Ian Meyers, Maxim Sidorov, Katharina Koeck, Rintaro Hashizume, Tomoko Ozawa, Joanna J Phillips, Mitchel S Berger, Theodore Nicolaides, C David James, Claudia K Petritsch

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