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Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion.

Yulun Huang, Lin Qi, Mari Kogiso, Yuchen Du, Frank K Braun, Huiyuan Zhang, L Frank Huang, Sophie Xiao, Wan-Yee Teo, Holly Lindsay, Sibo Zhao, Patricia Baxter, Jack M F Su, Adekunle Adesina, Jianhua Yang, Sebastian Brabetz, Marcel Kool, Stefan M Pfister, Murali Chintagumpala, Laszlo Perlaky, Zhong Wang, Youxin Zhou, Tsz-Kwong Man, Xiao-Nan Li

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Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies

Lin Qi, Holly Lindsay, Mari Kogiso, Yuchen Du, Frank K Braun, Huiyuan Zhang, Lei Guo, Sibo Zhao, Sarah G Injac, Patricia A Baxter, Jack Mf Su, Sophie Xiao, Stephen W Erickson, Eric J Earley, Beverly Teicher, Malcolm A Smith, Xiao-Nan Li

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Maximizing the potential of aggressive mouse tumor models in preclinical drug testing.

M Tarek Elghetany, Jia-Min Ho, Lois Hew Shi-Qi, Sekar Karthik, Jack M F Su, Qi Lin, YuChen Du, Jianhe Shen, Wing-Yuk Chow, Ching C Lau, Adekunle Adesina, Angela Major, Anat Erdreich-Epstein, Kam-Man Hui, Xiao-Nan Li, Wan-Yee Teo

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Functional precision medicine identifies new therapeutic candidates for medulloblastoma

Jessica M Rusert, Edwin F Juarez, Sebastian Brabetz, James Jensen, Alexandra Garancher, Lianne Q Chau, Silvia K Tacheva-Grigorova, Sameerah Wahab, Yoko T Udaka, Darren Finlay, Huriye Seker-Cin, Brendan Reardon, Susanne Gröbner, Jonathan Serrano, Jonas Ecker, Lin Qi, Mari Kogiso, Yuchen Du, Patricia A Baxter, Jacob J Henderson, Michael E Berens, Kristiina Vuori, Till Milde, Yoon-Jae Cho, Xiao-Nan Li, James M Olson, Iris Reyes, Matija Snuderl, Terence C Wong, David P Dimmock, Shareef A Nahas, Denise Malicki, John R Crawford, Michael L Levy, Eliezer M Van Allen, Stefan M Pfister, Pablo Tamayo, Marcel Kool, Jill P Mesirov, Robert J Wechsler-Reya

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Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-response in a large panel of orthotopic PDX models of pediatric brain tumors.

Lin Qi, Mari Kogiso, Yuchen Du, Huiyuan Zhang, Frank K Braun, Yulun Huang, Wan-Yee Teo, Holly Lindsay, Sibo Zhao, Patricia Baxter, Xiumei Zhao, Litian Yu, Zhigang Liu, Xingding Zhang, Jack Mf Su, Adekunle Adesina, Jianhua Yang, Murali Chintagumpala, Laszlo Perlaky, Chris Tsz-Kwong Man, Ching C Lau, Xiao-Nan Li

Publication

Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma.

Huiyuan Zhang, Lin Qi, Yuchen Du, L Frank Huang, Frank K Braun, Mari Kogiso, Yanling Zhao, Can Li, Holly Lindsay, Sibo Zhao, Sarah G Injac, Patricia A Baxter, Jack M Su, Clifford Stephan, Charles Keller, Kent A Heck, Akdes Harmanci, Arif O Harmanci, Jianhua Yang, Tiemo J Klisch, Xiao-Nan Li, Akash J Patel

Publication

Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma

Alexandra Garancher, Hiromichi Suzuki, Svasti Haricharan, Lianne Q Chau, Meher Beigi Masihi, Jessica M Rusert, Paula S Norris, Florent Carrette, Megan M Romero, Sorana A Morrissy, Patryk Skowron, Florence M G Cavalli, Hamza Farooq, Vijay Ramaswamy, Steven J M Jones, Richard A Moore, Andrew J Mungall, Yussanne Ma, Nina Thiessen, Yisu Li, Alaide Morcavallo, Lin Qi, Mari Kogiso, Yuchen Du, Patricia Baxter, Jacob J Henderson, John R Crawford, Michael L Levy, James M Olson, Yoon-Jae Cho, Aniruddha J Deshpande, Xiao-Nan Li, Louis Chesler, Marco A Marra, Harald Wajant, Oren J Becher, Linda M Bradley, Carl F Ware, Michael D Taylor, Robert J Wechsler-Reya

Publication

Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma.

Lei Huang, Sarah Garrett Injac, Kemi Cui, Frank Braun, Qi Lin, Yuchen Du, Huiyuan Zhang, Mari Kogiso, Holly Lindsay, Sibo Zhao, Patricia Baxter, Adesina Adekunle, Tsz-Kwong Man, Hong Zhao, Xiao-Nan Li, Ching C Lau, Stephen T C Wong

Publication

Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models.

Mari Kogiso, Lin Qi, Frank K Braun, Sarah G Injac, Linna Zhang, Yuchen Du, Huiyuan Zhang, Frank Y Lin, Sibo Zhao, Holly Lindsay, Jack M Su, Patricia A Baxter, Adekunle M Adesina, Debra Liao, Mark G Qian, Stacey Berg, Jodi A Muscal, Xiao-Nan Li

Publication

IL-13 receptors as possible therapeutic targets in diffuse intrinsic pontine glioma.

Noah E Berlow, Matthew N Svalina, Michael J Quist, Teagan P Settelmeyer, Viktor Zherebitskiy, Mari Kogiso, Lin Qi, Yuchen Du, Cynthia E Hawkins, Esther Hulleman, Xiao-Nan Li, Sakir H Gultekin, Charles Keller

Publication

Xenotransplantation of pediatric low grade gliomas confirms the enrichment of BRAF V600E mutation and preservation of CDKN2A deletion in a novel orthotopic xenograft mouse model of progressive pleomorphic xanthoastrocytoma

Mari Kogiso, Lin Qi, Holly Lindsay, Yulun Huang, Xiumei Zhao, Zhigang Liu, Frank K Braun, Yuchen Du, Huiyuan Zhang, Goeun Bae, Sibo Zhao, Sarah G Injac, Mary Sobieski, David Brunell, Vidya Mehta, Diep Tran, Jeffrey Murray, Patricia A Baxter, Xiao-Jun Yuan, Jack M Su, Adekunle Adesina, Laszlo Perlaky, Murali Chintagumpala, D Williams Parsons, Ching C Lau, Clifford C Stephan, Xinyan Lu, Xiao-Nan Li

Publication

Preservation of KIT genotype in a novel pair of patient-derived orthotopic xenograft mouse models of metastatic pediatric CNS germinoma

Holly Lindsay, Yulun Huang, Yuchen Du, Frank K Braun, Wan Yee Teo, Mari Kogiso, Lin Qi, Huiyuan Zhang, Sibo Zhao, Hua Mao, Frank Lin, Patricia Baxter, Jack M Su, Keita Terashima, Laszlo Perlaky, Murali Chintagumpala, Adekunle Adesina, Ching C Lau, D Williams Parsons, Xiao-Nan Li

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