To assess the global and segmental left ventricular (LV) native T1 and extracellular volume fraction (ECV) in children and young adults with hypertrophic cardiomyopathy (HCM) compared to a control cohort. The study population included 21 HCM patients (mean 14.1 ± 4.6 years) and 21 controls (mean 15.7 ± 1.5 years). Native modified Look-Locker inversion recovery sequence was performed before and after contrast injection in 3 short axis planes. Global and segmental LV native T1 and ECV were quantified and compared between HCM patients and controls. Mean native T1 in HCM patients and controls was 1020.4 ± 41.2 and 965.6 ± 30.2 ms respectively (p < 0.0001). hypertrophied myocardium had significantly higher native global t1 and global ecv compared to non-hypertrophied myocardium in hcm (p >< 0.0001, = 0.14 and 0.048, =" 0.01" respectively). in a subset of patients, ecv was higher in lv segments with lge compared to no lge (p >< 0.0001). no significant correlation was identified between global native t1 and ecv and parameters of lv structure and function. native t1 cut-off of 987 ms provided the highest sensitivity (95 %) and specificity (91 %) to separate hcm patients from controls. global and segmental native t1 are elevated in hcm patients. lv segments with hypertrophy and or lge had higher ecv in a subset of hcm patients. lv native t1 and ecv do not correlate with parameters of lv structure and function. t1 in children and young adults may be used as a non-invasive tool to assess for hcm and related fibrosis.>

DOI 10.1007/s10554-016-0979-9