Association of Virologic Failure and Nonnucleoside Reverse Transcriptase Inhibitor Resistance Found in Antiretroviral-Naive Children Infected With Human Immunodeficiency Virus and Given Efavirenz-Based Treatment.

Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (hiv) or coinfected with hiv and tuberculosis and initiating efavirenz-based antiretroviral therapy (art), non-nucleoside reverse transcriptase inhibitor (nnrti) resistance was detected before art in 5 (7.6%). virologic failure occurred in 2 of these children; they were last tested at 16 and 24 weeks of art. pre-art nnrti resistance was not associated with virologic failure.>

DOI 10.1093/jpids/piz038