Abstract
AIMS: To examine associations of pregnancy glycemia with future dyslipidemia. METHODS: We analyzed data from Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study participants. We examined associations of gestational diabetes (GDM), sum of fasting, 1-hour, and 2-hour glucose z-scores after 75-g load, insulin sensitivity, and lipid levels at 24-32 weeks' gestation with dyslipidemia 10-14 years postpartum. RESULTS: Among 4,693 women, 14.3% had GDM. At follow-up, mean (SD) age was 41.7 (5.7) years, 32.3% had total cholesterol (TC) ≥ 5.17, 27.2% had HDL cholesterol < 1.29, 22.4% had ldl cholesterol (ldl-c) ≥ 3.36, 10.9% had triglycerides ≥ 1.69 mmol l, and 2.9% had type 2 diabetes. after covariate adjustment, pregnancy glycemic measures were associated with all follow-up dyslipidemias. after additional adjustment for pregnancy lipids, gdm remained associated with tc ≥ 5.17 mmol l (odds ratio [95% ci], 1.63 [1.22-2.18]) and ldl-c ≥ 3.36 mmol l (1.63 [1.20-2.22]), even in the absence of type 2 diabetes development (1.55 [1.15-2.10] and 1.56 [1.13-2.16], respectively). continuous glycemic measures in pregnancy were significantly associated with all follow-up dyslipidemias, independent of pregnancy lipids and type 2 diabetes. conclusions: pregnancy glycemia was associated with dyslipidemia 10-14 years later, independent of pregnancy lipid levels and in the absence of type 2 diabetes development. lipid screening after gdm deserves special consideration.>
