Abstract
Hidradenitis suppurativa (HS), also known as acne inversa, is a recurring, painful, chronic, and sometimes disfiguring inflammatory skin disease. Our objective was to report the baseline clinical characteristics, natural history, and associated outcomes of patients with HS from the ongoing, prospective, non-interventional UNITE registry that is collecting data regarding the natural history and associated outcomes of HS. Patients with inflammatory HS lesions were enrolled, including adolescents (aged 12 to < 18 years) and adults (aged ≥ 18 years). none had participated in previous or current originator-adalimumab studies registries. patients received treatment consistent with site-specific, routine clinical practice. hs disease status was assessed by hs lesions and disease flare; treatment and outcomes data were collected at enrolment and every 6 months for ≤ 4 years. enrolment (n =" 594;" 89.1% adults; 10.9% adolescents) occurred from 29 october 2013 to 29 december 2015 at 73 sites in 12 countries. at baseline, the majority were female (69.7%) and white (81.2%), had moderate-to-severe disease (hurley stage ii or iii; 93.3%), and had undergone prior procedures surgery for hs (68.7%). in total, 61.6% of adults and 49.2% of adolescents were obese; 40.2% of patients reported current tobacco use. scarring due to lesions occurred in 91.2% of patients. the prevalence of comorbidities of interest was as follows: depression (13.3%), other psychiatric disorders (9.6%), inflammatory bowel disease (2.7%), diabetes (9.1%), and polycystic ovary syndrome (5.2%). in this population from the unite hs registry, obesity and smoking were common, and disease burden was high, manifesting as multiple lesions, scarring, surgical history, and considerable comorbidities.>
