Abstract
There is a paucity of longitudinal data on cardiac outcomes in multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19. We aimed to investigate the longitudinal cardiovascular outcomes in MIS-C. PubMed and EMBASE were searched through May 2022. Observational studies were included, reporting mid-term (≥ 3 months) outcomes in children (aged < 21) with mis-c. data were extracted by two researchers. longitudinal outcomes were synthesized by a one-group meta-analysis using a random-effects model. eleven studies with a follow-up period (3 months to 1 year) were identified, including 547 mis-c patients. the mortality was 2.5% (95% ci 1.3-4.9). the majority of left ventricular (lv) systolic dysfunction present in 46.8% (95% ci 32.7-61.3) in the acute phase resolved by 3 months, and the prevalence of lv systolic dysfunction was 1.7% (95% ci 0.5-5.7) and 2.1% (95% ci 0.8-5.4) at 3 month and 6 month follow-up, respectively. additionally, the persistent lv systolic dysfunction in the small population was mild. however, coronary abnormalities such as coronary artery dilatation or aneurysms, seen in 23.7% (95% ci 17.7-31.1) at baseline, persisted in 4.7% (95% ci 1.5-14.3) at 3 months and 5.2% (95% ci 3.0-8.9) at 6 months. mitral regurgitation (mr), which was observed in 56.6% (95% ci 27.7-81.6) at baseline, also persisted in 7.5% at 6 months. in conclusion, our study demonstrated largely favorable cardiac outcomes, suggesting resolution of lv systolic dysfunction in the majority of cases. however, coronary abnormalities and mr persisted in a subset of patients at mid-term follow-up. media, llc, part of springer nature.>
