Abstract
OBJECTIVE: To determine whether nativity is associated with abdominal wall defects among births to Mexican-American women. STUDY DESIGN: Using a cross-sectional, population-based design, stratified and multivariable logistic regression analyses were performed on the 2014-2017 National Center for Health Statistics live-birth cohort dataset of infants of US-born (n = 1 398 719) and foreign-born (n = 1 221 411) Mexican-American women. RESULTS: The incidence of gastroschisis was greater among births to US-born compared with Mexico-born Mexican-American women: 36.7/100 000 vs 15.5/100 000, RR = 2.4 (2.0, 2.9). US-born (compared with Mexico-born) Mexican-American mothers had a greater percentage of teens and cigarette smokers, P < .0001. in both subgroups, gastroschisis rates were greatest among teens and decreased with advancing maternal age. adjusting for maternal age, parity, education, cigarette smoking, pre-pregnancy body mass index, prenatal care usage, and infant sex), or of gastroschisis for us-born (compared with mexico-born) mexican-american women was 1.7 (95% ci 1.4-2.0). the population attributable risk of maternal birth in the us for gastroschisis equaled 43%. the incidence of omphalocele did not vary by maternal nativity. conclusions: mexican-american women's birth in the us vs mexico is an independent risk factor for gastroschisis but not omphalocele. moreover, a substantial proportion of gastroschisis lesions among mexican-american infants is attributable to factors closely related to their mother's nativity.>
